Frank Lampard's Chelsea make the trip Merseyside to face Everton.
Watford have confirmed the appointment of Nigel Pearson, taking over from Quique Sanchez Flores.
Bournemouth host Liverpool at the Vitality Stadium.
After defeat at Old Trafford on Wednesday, Jose Mourinho's Tottenham host Burnley on Saturday.
Manchester United travel across the city to face their noisy neighbours.
Goals from Adam Webster and Neal Maupay either side of an Alexandre Lacazette equaliser confounded Arsenal's misery as Brighton triumphed…
Marco Silva has been sacked as manager of Everton after the Toffees' poor early season form.
Liverpool thrashed Everton 5-2 in a devastatingly clinical performance from Jurgen Klopp's men.
Brighton travel to London to face a vulnerable Arsenal side.
In the fourth opening of the Prost International Advent Calendar, Chris previews tonight's fixture between Liverpool and Everton.